Like other body tissues, human skin undergoes the process of growth, development and aging. Usually from the age of 25, human skin begins to age, and its skin tissue and its functions begin to decline, which is called the early aging stage, which is mainly manifested in thinning of the skin, reduction of subcutaneous fat, decreased secretion of sebaceous glands and sweat glands, and skin appearance. Dryness, dehydration and other phenomena, the skin then loses its former luster. The pathological basis of skin aging is epidermal thinning, dermal fiber rupture, and fat atrophy. Then, the most direct consequence of skin thinning and dermal elastic fiber rupture is the appearance of wrinkles.